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Nanna Glerup's PhD defense

 9.15 - 10.00 Daniel Rueckert, Imperial College, London
10.15 - 11.00 Gabor Szekely, ETH, Zurich

13.00 -       Nanna Glerup on Quantification of asymmetry in medical image
              analysis, PhD Defense

Room 2A14 at ITU

Medical Image Registration in Healthcare, Biomedical Research and Drug Discovery

Daniel Rueckert

Imaging technologies are developing at a rapid pace allowing for in-vivo 3D and 4D imaging of the anatomy and physiology in humans and animals. This is opening up unprecedented opportunities for research and clinical applications ranging from imaging for drug discovery and delivery, over imaging for diagnosis and therapy, to imaging for basic research such as brain mapping. In this talk we will focus on how computational techniques based on non-rigid image registration can be used to address the image analysis challenges in healthcare, biomedical research and drug discovery.

Modeling and simulation of tissue formation and growth

Gaor Szekely

Tissue formation is an extremely complex biological process, influenced by a large number of genetic, biochemical and biophysical factors. While the genetic and molecular biological aspects have been subject to intensive research, limited efforts have been taken up to now to investigate the influence of biophysical processes on tissue development, and the possible contributions which classical engineering approaches could provide to enhance our understanding. This talk summarizes our current work aiming at constructing structural models and simulation techniques, allowing to investigate the role of biomechanics and fluid dynamics in tissue growth and remodeling. Results on two relevant areas will be reported about. First the simulation of tumour growth using a particle model will be presented and discussed. This approach allows for the modeling of tumour genesis, i.e. the process from the emergence of a single tumor cell to its macroscopic finding and offers a straightforward way to incorporate relevant physiological and biomechanical aspects, like the mechanical forces generated by the dynamic rearrangements of cell-cell contacts and the cytoskeleton. The second part of the talk will concentrate on recent results of our investigations, how the interaction of blood flow and the tissue may influence the angiogenesis process. Models of the flow-driven remodeling of the capillary plexus as well as a computational playground for the numerical simulations of micro-vascular structure formation by intussusceptive angiogenesis will be presented and discussed.

Quantification of asymmetry in medical image analysis

Nanna Glerup, PhD Defense

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