Modeling of beta-cells
Paul Matthias Diderichsen
Department of Physics, Technical University of Denmark,
DK-2800 Kgs. Lyngby, Denmark
Department of Scientific Computing,
Novo Nordisk, DK-2760 Måløv, Denmark
A typical beta-cell model may be constructed using a number of components
which define the ionic currents, the variation in intracellular concentrations,
and various couplings. In this presentation, a number of bursting beta-cell
models will be examined and compared, and the components involved will be
explained and discussed.
It will be shown that a majority of the models implement one of two
mechanisms to produce the bursting membrane potential oscillations:
One involves a calcium dependent activation of a potassium current while
the other is based on a slow inhibition of the calcium current.