Graduate School in Nonlinear Science

Sponsored by the Danish Research Academy

MIDIT                               OFD                           CATS
Modelling, Nonlinear Dynamics       Optics and Fluid Dynamics     Chaos and Turbulence Studies
and Irreversible Thermodynamics     Risø National Laboratory      Niels Bohr Institute and 
Technical University of Denmark     Building 128                  Department of Chemistry
Building 321                        P.O. Box 49                   University of Copenhagen 
DK-2800 Lyngby                      DK-4000 Roskilde              DK-2100 Copenhagen Ø
Denmark                             Denmark                       Denmark


by Arthur Sherman
National Institute of Health
Wisconsin, Bethesda, USA

MIDIT-seminar 444

Wednesday April 14, 1999, 14.00 h
at MIDIT, IMM Building 305, room 053

Abstract: We have shown that electrical coupling of pancreatic beta-cells may be important not only for synchronizing oscillations, but for the generation of those oscillations. That is, one can demonstrate cases in which none of the individual cells are capable of bursting, but the coupled population is. In addition, even if the cells are burst capable, the coupled cells may exhibit significantly lengthened periods. These effects all depend on the asynchrony of the spikes within a burst, and many patterns of asynchrony (anti-phase, quasi-periodic, asymmetric) are possible. Consideration of heterogeneous cells, the most likely case, suggests that the asymmetric pattern will predominate.