$PROBLEM PSMValidation

$INPUT ID TIME EVID DV CMT AMT

$DATA NONMEMinputdata.csv  IGNORE "

$SUBROUTINE ADVAN6 TOL 6 DP

$MODEL
COMP=(CENTRAL)
COMP=(PERIPH)


$THETA (0 0.6) ; W
$THETA (0 5 50) ; V1

$OMEGA 0.5     ; V1

$SIGMA 1 FIX

$PK
K1 = 0.005
K2 = 0.005
K3 = 0.002  

V1 = THETA(2) * EXP(ETA(1))

$DES
DADT(1)= -(K1+K3)*A(1) + K2*A(2)
DADT(2)= K1*A(1)-K2*A(2) 

$ERROR
IPRED=A(1)/V1
IRES=DV-IPRED
W=THETA(1)
IWRES=IRES/W
Y=IPRED+W*EPS(1)

$ESTIMATION MAXEVALS=9999 METHOD=1 INTERACTION NOABORT SIGDIGITS=3 PRINT=5

$COVARIANCE

$TABLE ID TIME EVID IPRED IRES IWRES W ETA(1) 
       NOPRINT ONEHEADER FILE=TABLE.PAR

