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Title: Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding
Type: Journal articleJournal article
Participant(s):
Forfatter:  Frokjaer, Vibe G.
Copenhagen University Hospital, Center for Integrated Molecular Brain Imaging

Forfatter:  Erritzoe, David
Copenhagen University Hospital, Center for Integrated Molecular Brain Imaging

Forfatter:  Juul, Anders
Copenhagen University Hospital, Department of Growth and Reproduction

Author:  Nielsen, Finn Årup (Cwisno: 1755)
Technical University of Denmark
Email:

Forfatter:  Holst, Klaus
University of Copenhagen, Department of Biostatistics

Forfatter:  Svarer, Claus
Copenhagen University Hospital, Neurobiology Research Unit

Forfatter:  Madsen, Jacob
Copenhagen University Hospital, PET and Cyclotron Unit

Forfatter:  Paulson, Olaf B.
Hvidovre University Hospital, Danish Research Centre for Magnetic Resonance

Forfatter:  Knudsen, Gitte Moos
Copenhagen University Hospital, Center for Integrated Molecular Brain Imaging
Abstract: Background: Sex-hormones influence brain function and are likely to play a role in the gender predisposition to mood and anxiety disorders. Acute fluctuations of sex-hormone levels including hormonal replacement therapy appear to affect serotonergic neurotransmission, but it is unknown if baseline levels affect serotonergic neurotransmission. This study was undertaken to examine if baseline levels of endogenous sex hormones are associated with cerebral serotonin 2A (5-HT2A) receptor binding in men. Methods: In a group of 72 healthy men (mean age 37.5 years ±17.4 SD, range 19.6–81.7) we studied the effect of plasma sex hormone levels on neocortical 5-HT2A receptor binding as imaged with [18F]altanserin PET. The effect of endogenous sex-hormone levels was evaluated by multiple linear regression analysis. Results: Mean neocortical 5-HT2A receptor binding was positively correlated with estradiol (p = 0.0001), whereas no independent effects of testosterone could be demonstrated. Correction for other factors of importance for 5-HT2A receptor binding did not change the result. A voxel-based analysis suggested that there were no regional differences in the estradiol effect on cortical 5-HT2A receptor binding. Conclusions: Our data show a positive correlation between endogenous plasma estradiol levels and cortical 5-HT2A receptor binding in healthy men, whereas, no independent effect of testosterone was demonstrated. We speculate that this association could be mediated through effects on gene transcription.
Published: in journal: Psychoneuroendocrinology (ISSN: 0306-4530) (DOI: http://dx.doi.org/10.1016/j.psyneuen.2010.03.002), vol: 35, issue: 9, pages: 1311-1320, 2010
DOI:
See the publication in DTU Orbit See the publication in DTU Orbit

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